Order Number |
01532547897 |
Type of Project |
ESSAY |
Writer Level |
PHD VERIFIED |
Format |
APA |
Academic Sources |
10 |
Page Count |
3-12 PAGES |
Choose ONE of the discussion questions below.
Please post your initial and Respond to one student. All responses must be a minimum of 150 words, scholarly written, APA formatted, and referenced. A minimum of 2 references.
Cell Biology Article Assignment
Cell Biology – Article Assignment #2
THE ARTICLE FOR THIS ASSIGNMENT CAN BE FOUND AT: https://jcp.bmj.com/content/73/7/366.long
HOW TO DO THIS ASSIGNMENT-
1a. What does each part of “2019-nCoV/SARS-CoV-2” mean?
ANSWER
1b. What does “novel coronavirus” mean?
ANSWER
1c. What does “spike protein” mean?
ANSWER
REFERENCE(S):
2a. What does the phrase “protein homology” mean?
ANSWER
2b. Explain how “protein homology” is related to “gene homology”.
ANSWER
REFERENCE(S):
3a. According to this article, how much homology is there between the SARS-CoV-2 spike protein and the spike protein of viruses found in pangolins and bats?
ANSWER
3b. What is a “pangolin”? And what do pangolins and bats have to do with SARS-Co-V-2?
ANSWER
REFERENCE(S):
4a. According to this article, what is the size of the coronavirus (in nm)? ANSWER
4b. According to this article, what is the size of the coronavirus (in mm)? ANSWER
4c. According to this article, what is the size of a spike protein (in nm)? ANSWER
4d. According to this article, what is the size of a spike protein (in mm)? ANSWER
REFERENCE(S):
5a. According to this article, what is the name of the enzyme that copies the viral RNA genome into mRNAs? ANSWER
5b. According to this article, PCR tests for viral infection usually test for which THREE viral proteins? ANSWER
REFERENCE(S):
6a. The spike protein has ANSWER (fill in) amino acids.
6b. The spike protein has a specific quaternary structure which is described as ANSWER
6c. The monomer of a spike protein is ANSWER (fill in) kilodaltons.
REFERENCE(S):
7a. What is the function of the S1 region? ANSWER
7b. What is the function of the S2 region? ANSWER
7c. What it the name of the enzyme that cleaves the spike protein into S1 and S2? ANSWER
REFERENCE(S):
8a. What is the “RBD”? ANSWER
8b. Which part of the spike protein has the RBD? ANSWER
8c. Which human protein binds to the spike’s RBD? ANSWER
8d The RBD has two conformations, the “up” and “down” conformations. What is the advantage of having these two conformations if only one shape works for attaching to cells?
ANSWER
REFERENCE(S):
9a. What is TMPSSR2? ANSWER
9b. Is TMPSSR2 a viral protein or a human host protein? ANSWER
9c. What happens when TMPSSR2 does its job? ANSWER
REFERENCE(S):
10a. The “delta variant” of the coronavirus has many mutations, including some in the RBD. Explain how these mutations might affect how CONTAGIOUS the virus is?
ANSWER
10b. The “delta variant” of the coronavirus has many mutations, including some in the RBD. Explain how these mutations might affect how well (or poorly) ANTIBODIES made to the alpha variant protect individual humans from infection.
ANSWER
REFERENCE(S):
REMEMBER – You will not get credit for your answers if you
OR